Low dose naltrexone (LDN) is used by many people for autoimmune conditions, chronic pain, inflammation, and other health issues. While LDN can be helpful, it’s important to know what to avoid so you get the best results and prevent side effects.
What is Low Dose Naltrexone (LDN)?
Naltrexone is normally used in higher doses (50mg) to treat alcohol and opioid dependence. Low dose naltrexone (1mg–5mg) works differently. At this small amount, it helps regulate the immune system, lower inflammation, and reduce pain.
But to get the best benefits, you need to avoid certain things while on LDN.
What to Avoid When Taking Low Dose Naltrexone
1. Opioid Pain Medications
LDN blocks opioid receptors. If you take opioids (like morphine, codeine, hydrocodone, oxycodone, tramadol, or fentanyl), they won’t work properly and you may experience withdrawal.
🚫 Avoid opioids completely when on LDN.
2. Alcohol in Large Amounts
LDN is not the same as full-dose naltrexone, but alcohol can still stress your liver. Small social drinking is usually fine, but heavy alcohol use should be avoided.
3. Immunosuppressive Drugs (Check with Doctor)
Since LDN helps modulate the immune system, mixing it with strong immunosuppressants (like steroids, methotrexate, or biologics) may cause interactions. Always check with your doctor.
4. Taking LDN Too Close to Food or Supplements
LDN is usually best taken at night on an empty stomach. Food or supplements may slow absorption. Try to take it 2–3 hours after eating.
5. High-Dose Naltrexone Confusion
Do not confuse LDN with standard 50mg naltrexone. Taking the wrong dose can block your body’s natural endorphins for too long and cause unwanted effects.
6. Certain Sleep Aids
Some people notice vivid dreams or sleep changes with LDN. Avoid adding strong sleep medications unless advised by your doctor.
How Much and How Often to Take LDN
- Usual starting dose: 1.5mg at night
- Gradually increased to 3mg–4.5mg daily
- Always follow your doctor’s advice
- Do not double dose if you miss a pill
Foods That Are Safe with LDN
- Fresh vegetables (spinach, lettuce, kale, carrots, cucumbers)
- Fruits in moderation (berries, apples, pears, bananas)
- Lean proteins (chicken, fish, turkey, eggs)
- Whole grains and nuts
- Plenty of water
Common Questions People Ask
1. Can I take supplements with LDN?
Yes, most vitamins and supplements are safe. Just avoid taking them at the exact same time.
2. Can I drink coffee while on LDN?
Yes, coffee and tea are safe. Just don’t take LDN with caffeine together — keep a few hours gap.
3. Can I take LDN in the morning?
Yes, but most people prefer night-time because it works with natural endorphin release.
4. Can I take LDN while pregnant or breastfeeding?
Not enough research is available. Always ask your doctor first.
5. Can I take ibuprofen or Tylenol with LDN?
Yes, these are safe and not affected by LDN.
6. How long before I see results?
It can take 4–8 weeks before improvements are noticed.
7. Can I take LDN forever?
Yes, many people use it long-term safely.
8. What happens if I miss a dose?
Just skip it and take the next one at the regular time.
9. Can I combine LDN with antidepressants?
Yes, in most cases it is safe, but check with your doctor.
10. Is LDN addictive?
No, LDN is not addictive and does not cause dependence.
Final Thoughts
Low dose naltrexone can be very helpful for many conditions, but to get the full benefit you must avoid opioids, heavy alcohol, and certain drug interactions. Always take it as prescribed and check with your doctor if you’re unsure about combining it with other medicines.